Sayadaw U Thitzana was born in December 1951 in a village about 225 kilometres northwest of Mandalay in Upper Myanmar. He became a novice in 1960 at Kan Oo Monastery in Lhaw-gar village near Monywa. He then continued his studies at Ma-Soe-Yein Monastery in Mandalay, the largest study monastery in Myanmar, where today nearly three thousand monks and young novices study. Sayadaw would later obtain the title of Dvipiṭakadhāra by passing the Vinaya & Suttanta Piṭaka memorization examinations. From 1970, he began teaching pāli, Abhidhamma (Buddhist psychology) and scriptures at Ma-Soe-Yein for seven years before moving to Pañcanikāya Sāsana Beikman Monastery in Yangon to lead the teaching of monks and novices from 1978 to 1995. At the same time, from 1973, Sayadaw practised intensive meditation at the Mahāsi Meditation Centre under the guidance of the venerable U Sujāta and U Pandita. He also practised ānāpānasati with the Venerable Sun Lun. Since May 1995, Sayadaw has been based in the United States where he has established Dhammasukha Monastery in Los Angeles. Sayadaw U Thitzana currently resides at Asokarama Monastery established in 2015 in Charlotte, Michigan, where he is the principal abbot.